Vaccine thread

[Johngould21]

25 minutes ago, RupertKBD said:

 

I think it means he has a lot of jam....

 

(and here I go, sidetracking....but I couldn't resist... )

I'd love to see "marmalade"

[the destroyer of worlds]

1 hour ago, RupertKBD said:

 

Two takeaways from this article....

 

This paragraph struck me as very exciting news:

 

 

...and...

 

For a supposed "genius", Elon is a putz....

I always post this review article from 2018 ( https://www.nature.com/articles/nrd.2017.243  ) when retorting certain anti-vaxx talking points.  mRNA vaccines/treatments were coming.  Covid just forced things.  An inproved mRNA flu vaccine is likely for the 24/25 season.  The mRNA revolution will be televised.

[Warhippy]

2 hours ago, bolt said:

Almost as bad as Trudeau's incompetence and corruption leading up to bringing in a Nazi to celebrate at the House of Commons.  The Liberals then entered a motion to remove the video from the public record.  Even CNN is reporting that Trudeau is a complete putz.

Can you even name one compotent Liberal minister?

 

1 hour ago, bolt said:

Speaker Rota it was his fault alone

Judy Wilson Raybould it was her fault alone

Bill Morneau it was his fault alone.

Dr Philpot, it was her fault alone

.....

You obviously don't watch the HOC question period if you think the Liberals answer questions "as they should"

 

I forgot Justin Trudeau is very accountable and compotent.  I wonder why his poll numbers are flirting in the 10-20% range?

 

Take it to the appropriate thread and stay on topic.  Derailing threads is frowned upon at best.

[Johngould21]

On 10/2/2023 at 9:58 AM, Gurn said:

https://www.msn.com/en-ca/health/other/nobel-in-medicine-goes-to-2-scientists-whose-work-enabled-creation-of-mrna-vaccines-against-covid-19/ar-AA1hy8ph?bncnt=BroadcastNews_BreakingNews&ocid=UCPNC2&FORM=BNC001&pc=U531&cvid=65819b00c07b4c56a59238ed1a98e17c&ei=13#image=1

"

STOCKHOLM (AP) — Two scientists won the Nobel Prize in medicine on Monday for discoveries that enabled the creation of mRNA vaccines against COVID-19 that were critical in slowing the pandemic — technology that's also being studied to fight cancer and other diseases.

Hungarian-American Katalin Karikó and American Drew Weissman were cited for contributing “to the unprecedented rate of vaccine development during one of the greatest threats to human health,” according to the panel that awarded the prize in Stockholm.

The panel said the pair's “groundbreaking findings ... fundamentally changed our understanding of how mRNA interacts with our immune system."

Traditionally, making vaccines required growing viruses or pieces of viruses and then purifying them before next steps. The messenger RNA approach starts with a snippet of genetic code carrying instructions for making proteins. Pick the right virus protein to target, and the body turns into a mini vaccine factory.

But in early experiments with animals, simply injecting lab-grown mRNA triggered a reaction that usually destroyed it. Karikó, a professor at Szeged University in Hungary and an adjunct professor at the University of Pennsylvania, and Weissman, of the University of Pennsylvania, figured out a tiny modification to the building blocks of RNA that made it stealthy enough to slip past immune defenses.

Karikó, 68, is the 13th woman to win the Nobel Prize in medicine. She was a senior vice president at BioNTech, which partnered with Pfizer to make one of the COVID-19 vaccines. Karikó and Weissman, 64, met by chance in the 1990s while photocopying research papers, Karikó told The Associated Press.

WHY DO MRNA VACCINES MATTER?

Dr. Paul Hunter, a professor of medicine at Britain’s University of East Anglia, described the mRNA vaccines made by BioNTech-Pfizer and Moderna Inc. as a “game changer” in shutting down the coronavirus pandemic, crediting the shots with saving millions of lives.

“We would likely only now be coming out of the depths of COVID without the mRNA vaccines,” Hunter said.

John Tregoning, of Imperial College London, called Karikó “one of the most inspirational scientists I have met.” Her work together with Weissmann "shows the importance of basic, fundamental research in the path to solutions to the most pressing societal needs,” he said in a statement.

The duo's pivotal mRNA research was combined with two other earlier scientific discoveries to create the COVID-19 vaccines. Researchers in Canada had developed a fatty coating to help mRNA get inside cells to do its work. And studies with prior vaccines at the U.S. National Institutes of Health showed how to stabilize the coronavirus spike protein that the new mRNA shots needed to deliver.

Dr. Bharat Pankhania, an infectious diseases expert at Exeter University, predicted the technology used in the vaccines could be used to refine vaccines for other diseases like Ebola, malaria and dengue, and might also be used to create shots that immunize people against certain types of cancer or auto-immune diseases including lupus.

Peter Maybarduk, at the Washington advocacy group Public Citizen, welcomed the recognition of mRNA vaccines, but said the award should also be deeply embarrassing for Western countries.

“This is a technology that should have been available to all of humanity but it was almost exclusively available only in the richest countries in the world,” he said, adding that much of the funding that led to the development of mRNA technology came from U.S. public funds.

HOW DID KARIKÓ AND WEISSMAN REACT?

“The future is just so incredible,” Weissman said. “We’ve been thinking for years about everything that we could do with RNA, and now it’s here.”

Karikó said her husband was the first to pick up the early morning call, handing it to her to hear the news. She then watched the announcement to make sure she wasn't being pranked.

"I was very much surprised. But I am very happy.”

Karikó said she was the one to break the news to Weissman, since she got in touch before the Nobel committee could reach him.

The two have collaborated for decades, with Karikó focusing on the RNA side and Weissman handling the immunology: “We educated each other,” she said.

Before COVID-19, mRNA vaccines were already being tested for other diseases like Zika, influenza and rabies — but the pandemic brought more attention to this approach, Karikó said. It's also being tested for cancer immunotherapy.

“There was already clinical trials before COVID, but people were not aware,” she said.

Karikó's family are no strangers to high honors. Her daughter, Susan Francia, is a double Olympic gold medalist in rowing, competing for the United States.

The prize carries a cash award of 11 million Swedish kronor ($1 million) — from a bequest left by the prize’s creator, Swedish inventor Alfred Nobel. The laureates are invited to receive their awards at ceremonies on Dec. 10, the anniversary of Nobel’s death.

Nobel announcements continue with the physics prize on Tuesday, chemistry on Wednesday and literature on Thursday. The Nobel Peace Prize will be announced Friday and the economics award on Oct. 9.

___

This story has been updated to correct that Karikó is a professor at Szeged Uniiversity, not Sagan’s University.

I watched the news last night, and thought I heard something along the lines of their research almost being mothballed. They had to beg the University to allow them to continue with their research. Can someone elaborate? So, those who thought that this is a new vaccine, cough, cough, antivaxxers, do a bit of research on your own.

[Satchmo]

15 minutes ago, Johngould21 said:

I watched the news last night, and thought I heard something along the lines of their research almost being mothballed. They had to beg the University to allow them to continue with their research. Can someone elaborate? So, those who thought that this is a new vaccine, cough, cough, antivaxxers, do a bit of research on your own.

These two have been focusing on the idea of mRNA vaccines since the late nineties. Before that, Kariko had studied mNRA for years and Weissmann worked on HIV vaccines.  They met at a conference and decided to work together. Just about no one else thought the idea would ever work.  They had to struggle to get funding, especially in the early years.

 

Persistentance paid off well in this case. 

[Johngould21]

1 hour ago, Satchmo said:

These two have been focusing on the idea of mRNA vaccines since the late nineties. Before that, Kariko had studied mNRA for years and Weissmann worked on HIV vaccines.  They met at a conference and decided to work together. Just about no one else thought the idea would ever work.  They had to struggle to get funding, especially in the early years.

 

Persistentance paid off well in this case. 

Thanks for confirming what I thought I heard. 

[The Arrogant Worms]

[Sharpshooter]

3 hours ago, The Arrogant Worms said:

Well said indeed. 

[Bob Long]

Just an interesting piece from an industry source I read about vaccine disinformation:

 

Organized Disinformation Fanning the COVID-19 Flames of Vaccine Hesitancy   

September 18, 2023

Kevin Kavanagh, MD

 

Randomized controlled trials show masks are effective. With COVID-19, even one mistake in protective gear usage could lead to infection and obscure results.

 

Our pandemic response has undoubtedly been stymied, largely due to the divisive effects of organized disinformation. Early in the pandemic, nearly half the COVID-19 information on Twitter (now X) was flagged as posted by bots that appeared to follow the propaganda playbooks of Chinese and Russian Intelligence. A European Union document came to similar conclusions, stating that Russian propaganda campaigns pushing fake news in multiple languages were designed to hinder the EU’s pandemic response. Most recently, the Washington Post reported that Russia had 100s thousands of phony online sites and social media bots and that only 1% have been detected. Putin's “Chef,” Yevgeny Prigozhin, widely conducted the Russian disinformation campaign. He also headed the notorious Wagner mercenary group and was indicted in the Mueller report concerning his interference in United States elections. We are dealing with a highly organized disinformation campaign designed to weaken our society on many levels.

 

"Many disseminators of disinformation downplay the idea of a multi-layer approach and proclaim that if you can still catch COVID-19 while wearing a mask, they do not work, ignoring that seldom is a single intervention 100% effective. Everything from treating a cold to cancer involves multilayer approaches, as does automobile and airline safety. Why should COVID-19 be any different?"

 

At the heart of many of these misleading posts is an all-or-nothing approach to infection control. For example, the contention that masks do not work is often based on studies that follow individuals in high-exposure settings for weeks or months. This was one of the fundamental flaws in many randomized controlled trials in the Cochrane report on masking. With highly infectious agents such as COVID-19, just one lapse in protective gear usage during the study could easily result in an infection and blunt any difference between the control and experimental groups.
 
One can easily see that interventions may lessen the likelihood of becoming infected, but as exposure time increases, the chances for a lapse in protection also increase. However, for the high-risk public (and I’m not sure who isn’t high risk for long COVID), wearing an N95 mask for a short encounter to pick up groceries or to enter a restaurant for a ‘take out’ home dinner makes sense and will markedly lessen your chances of becoming infected.

 

There is now evidence that it is not just the setting and exposure time that are important; viral dosage also plays an important role. Dosage concerns were mainly theoretical constructs until the publication of the recent study on prison populations by Margaret Lind, et al in Nature Communications. They found that during the Omicron wave, prior infection, vaccination, and hybrid immunity reduced the infection risk of residents without documented exposure and, to a lesser degree, in residents exposed in large areas (cellblocks). There was no reduction in infections with close exposure in small rooms (prison cells). Early in the pandemic, it was theorized that masks would help lessen the severity of disease by decreasing the amount of virus one is exposed to. This report adds credence to this assertion. The study also observed that hybrid immunity is best, further validating the recommendation for those previously infected to become vaccinated.
 
Thus, lowering the viral dosage will make it less likely to become infected and develop COVID-19 and long COVID. Masks and ventilation improvements are the best ways for individuals to add protection—hence a multilayered approach.
 
Many disseminators of disinformation downplay the idea of a multi-layer approach and proclaim that if you can still catch COVID-19 while wearing a mask, they do not work, ignoring that seldom is a single intervention 100% effective. Everything from treating a cold to cancer involves multilayer approaches, as does automobile and airline safety. Why should COVID-19 be any different?
 
As COVID-19 cases and hospitalizations increase, do not fall prey to disinformation. It is wise to be vaccine-boosted, wear a mask in high-risk settings, and carry a CO2 monitor to determine safe indoor ventilation. These steps will help us all avoid the disabilities caused by long COVID and help to maintain the health of our families and the nation’s workforce.

 

https://www.infectioncontroltoday.com/view/organized-disinformation-fanning-covid-19-flames-vaccine-hesitancy?utm_source=sfmc&utm_medium=email&utm_campaign=09292023_ICT_MOL-22-ICD0257_Molnycke_eNL INTL&eKey=bmFuY3lAcGtwYXJ0bmVycy5jYQ==

[The Arrogant Worms]

Finally got my Flu shot invite.  Booked for Sunday @ 8:30am

Edited October 10, 2023 by The Arrogant Worms

[Ryan Strome]

1 hour ago, The Arrogant Worms said:

Finally got my Flu shot invite.  Booked for Sunday @ 8:30am

Flu shot invite? What is going on in British Columbia? In Alberta You just walk into the drug store and get a flu shot

[Spur1]

5 minutes ago, Ryan Strome said:

Flu shot invite? What is going on in British Columbia? In Alberta You just walk into the drug store and get a flu shot

Not just a flu shot. Vaccine as well. 

[moosehead]

My neighbour just told me that on his online dating site.  The last 5 women have asked him about his covid vax.

They only want date guys  willing to get the covid vax ?    Makes sense i guess.  People are getting worried about this recent spike in covid cases. 

[King Heffy]

6 minutes ago, moosehead said:

My neighbour just told me that on his online dating site.  The last 5 women have asked him about his covid vax.

They only want date guys  willing to get the covid vax ?    Makes sense i guess.  People are getting worried about this recent spike in covid cases. 

Makes sense.  Apart from health reasons, I wouldn't date an antivaxxer simply because there's likely to be too many fundamental differences between our ways of thinking.

[Ryan Strome]

7 minutes ago, moosehead said:

My neighbour just told me that on his online dating site.  The last 5 women have asked him about his covid vax.

They only want date guys  willing to get the covid vax ?    Makes sense i guess.  People are getting worried about this recent spike in covid cases. 

Your neighbour sounds like he's either very picky or quite the Playboy..

[Spur1]

17 minutes ago, Spur1 said:

Not just a flu shot. Vaccine as well. 

Just got my notice today. 

[moosehead]

2 minutes ago, Ryan Strome said:

Your neighbour sounds like he's either very picky or quite the Playboy..

 

He has great hair.  Real flow.  Boeser flow. 

Edited October 10, 2023 by moosehead

[Cerridwen]

3 minutes ago, Spur1 said:

Just got my notice today. 

Got mine today, too.

[The Arrogant Worms]

50 minutes ago, Ryan Strome said:

Flu shot invite? What is going on in British Columbia? In Alberta You just walk into the drug store and get a flu shot

 

They changed it 2 years ago I think...or was it last year.

 

My wife thinks it is insane.  She still does not know how many flu shots her Pharmacy is getting.

[WeneedLumme]

1 hour ago, moosehead said:

My neighbour just told me that on his online dating site.  The last 5 women have asked him about his covid vax.

They only want date guys  willing to get the covid vax ?    Makes sense i guess.  People are getting worried about this recent spike in covid cases. 

One woman I know is the exact opposite. She claims that the MRNA vaccine changes our DNA so that she is now allergic to any physical contact with vaccinated people. 

[the destroyer of worlds]

Florida stopped posting COVID-19 data in 2021, just as Ron opened up the state.   We know the Delta wave ripped through the state, but data wasn't posted like a lot of other states and our provinces. 

 

https://www.newsweek.com/ron-desantis-loses-lawsuit-allowing-covid-data-released-1833216

Ron DeSantis Loses Fight to Limit COVID Data

[Spur1]

18 hours ago, WeneedLumme said:

One woman I know is the exact opposite. She claims that the MRNA vaccine changes our DNA so that she is now allergic to any physical contact with vaccinated people. 

I’m allergic to stupid people. Can’t help but think I would be allergic to her too. 

[moosehead]

Bc government should do a media campaign

 

covid vax makes u muscles grow

 

 

Edited October 11, 2023 by moosehead

[Ryan Strome]

19 hours ago, WeneedLumme said:

One woman I know is the exact opposite. She claims that the MRNA vaccine changes our DNA so that she is now allergic to any physical contact with vaccinated people. 

Hmmm... sounds like an excuse..

3 minutes ago, moosehead said:

Bc government should do a media campaign

 

covid vax makes u muscles grow

 

 

I mean governments have been lying about the covid vaccine for a couple years now. So what's another lie.

[The Arrogant Worms]

I am going to get my Covid shot on Sunday also.

 

Because I am not a wuss.